If you use AutoCAD and are comfortable with Layout Tabs, that's great. Maybe someday I will be in your shoes. However for those that are having a hard time with them, I came across a great tutorial which is here:
AutoCAD Layout Tabs
But even better, after you read through it (just so that you have a bit more information and knowledge) here is my "Cheat Sheet".
Just follow the steps and you will have your layout tab set up and scaled correctly. The only thing I do is measure my drawing in Model Space to see how large I want the page to be prior to creating the Layout. this is so I know what size to make the paper (see below). There might be easier ways, but I finally found this method that works for me!
1. Click on Layout Tab at the bottom of the AutoCAD screen.
2. Once there, right click.
3. Select Page Setup Manager
4. Choose your settings...printer, paper size, etc. Make sure the scale is 1:1 (not your drawing scale size).
5. Type MV
6. Pick two points and draw a rectangle to encompass the entire sheet.
7. Type MS
8. Set the scale. Go to top toolbar. Select View - Zoom - Scale
9. If your scale is, for example 1"=10', type on the Command line 1/10XP
10. Type PS
11. Click the border so it becomes bold and right click.
12. Choose Display. Make sure that you set it to "locked". This allows you to scroll in your drawing without messing up the scale.
That's it! I hope this was helpful.